Applied Sciences, Vol. 13, Pages 11864: The Q-Tube-Assisted Green Sustainable Synthesis of Fused Azines: New Synthetic Opportunities via Innovative Green Technology

Applied Sciences, Vol. 13, Pages 11864: The Q-Tube-Assisted Green Sustainable Synthesis of Fused Azines: New Synthetic Opportunities via Innovative Green Technology

Applied Sciences doi: 10.3390/app132111864

Authors: Abeer Nasser Al-Romaizan Salem M. Bawaked Tamer S. Saleh Mohamed Mokhtar M. Moustafa

An efficient, economical, and green, sustainable synthesis of fused azines using Mg-Al hydrotalcite under a high-pressure Q-Tube reactor has been developed. This reaction proceeds through the aza-Michael addition of α,β-unsaturated ketone with different aminoazoles. This method offered excellent yields in a short reaction time that economically saved energy in addition to the protocol showing the reuse of the catalyst seven times without losing its catalytic activity.