Cancers, Vol. 15, Pages 4355: New Prognostic Score (Essen Score) to Predict Postoperative Morbidity after Resection of Lung Metastases

Cancers, Vol. 15, Pages 4355: New Prognostic Score (Essen Score) to Predict Postoperative Morbidity after Resection of Lung Metastases

Cancers doi: 10.3390/cancers15174355

Authors: Konstantinos Grapatsas Fabian Dörr Hruy Menghesha Martin Schuler Viktor Grünwald Sebastian Bauer Hartmut H.-J. Schmidt Stephan Lang Rainer Kimmig Stefan Kasper Natalie Baldes Servet Bölükbas

Background: Pulmonary metastasectomy (PM) is a widely accepted surgical procedure. This study aims to investigate postoperative morbidity and mortality after PM and develop a score to predict high-risk patients. Methods: We retrospectively investigated all patients undergoing a PM in our institution from November 2012 to January 2023. Complications were defined as the diagnosis of any new disease after the PM up to 30 days after the operation. Results: 1284 patients were identified. At least one complication occurred in 145 patients (11.29%). Only one patient died during the hospital stay. Preoperative cardiovascular comorbidities (OR: 2.99, 95% CI: 1.412–3.744, p = 0.01), major lung resections (OR: 2.727, 95% CI: 1.678–4.431, p < 0.01), repeated pulmonary metastasectomy (OR: 1.759, 95% CI: 1.040–2.976, p = 0.03) and open thoracotomy (OR: 0.621, 95% CI: 0.415–0.930, p = 0.02) were identified as independent factors for postoperative complications. Based on the above independent factors for postoperative morbidity, the Essen score was developed (overall correct classification: 94.6%, ROC-Analysis: 0.828, 95% CI: 0.795–0.903). Conclusion: PM is a safe surgical procedure with acceptable morbidity and low mortality. The aim of the Essen score is to identify patients that are associated with risk for postoperative complications after PM.