Depression as a prognostic factor for conversion from mild cognitive impairment to all-cause dementia and Alzheimer's disease: a systematic review and meta-analysis of longitudinal studies

BackgroundMild cognitive impairment (MCI) is a transitional stage between normal aging and dementia, with annual conversion rates to Alzheimer's disease (AD) or all-cause dementia estimated at 10%−15%. The role of depression as a prognostic factor for dementia progression remains unclear. This systematic review and meta-analysis aimed to clarify the association between depression and risk of co...