Diagnostics, Vol. 14, Pages 902: Frugal and Translatable [15O]O2 Production for Human Inhalation with Direct Delivery from the Cyclotron to a Hybrid PET/MR

Diagnostics, Vol. 14, Pages 902: Frugal and Translatable [15O]O2 Production for Human Inhalation with Direct Delivery from the Cyclotron to a Hybrid PET/MR

Diagnostics doi: 10.3390/diagnostics14090902

Authors: Jeffrey Corsaut Elmer Soto Heather Biernaski Michael S. Kovacs Keith St. Lawrence Justin W. Hicks

Oxygen-15 (β+, t1/2 = 122 s) radiolabeled diatomic oxygen, in conjunction with positron emission tomography, is the gold standard to quantitatively measure the metabolic rate of oxygen consumption in the living human brain. We present herein a protocol for safe and effective delivery of [15O]O2 over 200 m to a human subject for inhalation. A frugal quality control testing procedure was devised and validated. This protocol can act as a blueprint for other sites seeking to implement similar imaging programs.