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IJMS, Vol. 24, Pages 10401: Molecular Pathways of Altered Brain Development in Fetuses Exposed to Hypoxia
International Journal of Molecular Sciences doi: 10.3390/ijms241210401
Authors: Anna Orzeł Katarzyna Unrug-Bielawska Dagmara Filipecka-Tyczka Krzysztof Berbeka Natalia Zeber-Lubecka Małgorzata Zielińska Anna Kajdy
Perinatal hypoxia is a major cause of neurodevelopmental impairment and subsequent motor and cognitive dysfunctions; it is associated with fetal growth restriction and uteroplacental dysfunction during pregnancy. This review aims to present the current knowledge on brain development resulting from perinatal asphyxia, including the causes, symptoms, and means of predicting the degree of brain damage. Furthermore, this review discusses the specificity of brain development in the growth-restricted fetus and how it is replicated and studied in animal models. Finally, this review aims at identifying the least understood and missing molecular pathways of abnormal brain development, especially with respect to potential treatment intervention.
