IJMS, Vol. 25, Pages 2145: Inflammation in Development and Aging: Insights from the Zebrafish Model

IJMS, Vol. 25, Pages 2145: Inflammation in Development and Aging: Insights from the Zebrafish Model

International Journal of Molecular Sciences doi: 10.3390/ijms25042145

Authors: Marta Mastrogiovanni Francisco Juan Martínez-Navarro Teresa V. Bowman María L. Cayuela

Zebrafish are an emergent animal model to study human diseases due to their significant genetic similarity to humans, swift development, and genetic manipulability. Their utility extends to the exploration of the involvement of inflammation in host defense, immune responses, and tissue regeneration. Additionally, the zebrafish model system facilitates prompt screening of chemical compounds that affect inflammation. This study explored the diverse roles of inflammatory pathways in zebrafish development and aging. Serving as a crucial model, zebrafish provides insights into the intricate interplay of inflammation in both developmental and aging contexts. The evidence presented suggests that the same inflammatory signaling pathways often play instructive or beneficial roles during embryogenesis and are associated with malignancies in adults.