JoF, Vol. 10, Pages 424: Secondary Metabolites from Marine-Derived Fungus Penicillium rubens BTBU20213035

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JoF, Vol. 10, Pages 424: Secondary Metabolites from Marine-Derived Fungus Penicillium rubens BTBU20213035

Journal of Fungi doi: 10.3390/jof10060424

Authors: Xiuli Xu Yifei Dong Jinpeng Yang Long Wang Linlin Ma Fuhang Song Xiaoli Ma

Two new polyketide derivatives, penirubenones A and B (1 and 2), and two naturally rare amino-bis-tetrahydrofuran derivatives, penirubenamides A and B (3 and 4), together with nine known compounds (5–13) were isolated from the marine-derived fungus Penicillium rubens BTBU20213035. The structures were identified by HRESIMS and 1D and 2D NMR analyses, and their absolute configurations were determined by a comparison of experimental and calculated electronic circular dichroism (ECD) spectroscopy and 13C NMR data. We found that 6 exhibited antibacterial activity against Staphylococcus aureus, with an MIC value of 3.125 μg/mL, and 1 and 2 showed synergistic antifungal activity against Candida albicans at 12.5 and 50 μg/mL with 0.0625 μg/mL rapamycin.

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