Molecules, Vol. 28, Pages 3753: Synthesis, Quality Control and Preliminary Activity Evaluation of a New Compound HM475

Molecules, Vol. 28, Pages 3753: Synthesis, Quality Control and Preliminary Activity Evaluation of a New Compound HM475

Molecules doi: 10.3390/molecules28093753

Authors: Jieqing Guo Luming Xie Jing Zhang Han Cao Juanxia Wang Xia Wu Yifan Feng

Based on the principle of molecular splicing and theory of traditional Chinese medicine pairs, a new multi-active compound (HM475) was synthesized by connecting metformin with honokiol, and its structure was characterized, which not only reduced the toxicity of raw materials, but also maintained the original activity, and had a certain significance in research and innovation. At the same time, quality control and preliminary activity evaluation were carried out, and the effect of HM475 on neuroinflammation was further explored, which provided a new idea for drug development of neurodegenerative diseases.