Molecules, Vol. 29, Pages 1608: Obtaining New Biocompatible Composite Materials with Antibacterial Properties Based on Diatomite and Biologically Active Compounds

Molecules, Vol. 29, Pages 1608: Obtaining New Biocompatible Composite Materials with Antibacterial Properties Based on Diatomite and Biologically Active Compounds

Molecules doi: 10.3390/molecules29071608

Authors: Saule Kabieva Gaziza Zhumanazarova Rymgul Zhaslan Gulistan Zhumabayeva Arthur Ukhov Dmitry Fedorishin Alexander Gubankov Farkhad Tarikhov Ordabay Yerkhan Kurzina Irina Rakhmetulla Yerkassov Abdigali Bakibaev

This study aimed to create new composite materials based on diatomite—a non-organic porous compound—through its surface modification with bioactive organic compounds, both synthetic and natural. Chloramphenicol, tetrahydroxymethylglycoluril and betulin were used as modifying substances. Composite materials were obtained by covering the diatomite surface with bioactive substance compounds as a solution and material dispersion in it. The materials were characterized by IR spectroscopy, SEM and X-ray photoelectron spectroscopy. For the biocomposites, the hemolytic effect, plasma proteins’ adsorption on the surface and the antibacterial activity of the obtained materials were studied. Results show that the obtained materials are promising for medicine and agriculture.