Viruses, Vol. 16, Pages 3: The Era of the FLips: How Spike Mutations L455F and F456L (and A475V) Are Shaping SARS-CoV-2 Evolution

Viruses, Vol. 16, Pages 3: The Era of the FLips: How Spike Mutations L455F and F456L (and A475V) Are Shaping SARS-CoV-2 Evolution

Viruses doi: 10.3390/v16010003

Authors: Daniele Focosi Pietro Giorgio Spezia Federico Gueli Fabrizio Maggi

Convergent evolution of the SARS-CoV-2 Spike protein has been mostly driven by immune escape, in particular by escape to the viral infection-neutralizing antibodies (nAbs) elicited by previous infections and/or vaccinations [...]